Family Physicians of Spartanburg

Family Physicians of Spartanburg is a medical clinic in Spartanburg, SC. The practice has provided family care to the Upstate of SC since 1974 and operates as the largest private non-hospital owned family practice in Spartanburg, serving Spartanburg, Duncan, Boiling Springs, and the surrounding Upstate area. It functions as a single-source primary care provider offering comprehensive in-house specialties and services that include an on-site retail pharmacy dispensary, laboratory services, radiology and x-ray facilities, ultrasound, nuclear medicine, and ABI monitoring. Patients can manage their health information, including labs, medications, appointments, billing, and payments, through a secure online patient portal and the Healow mobile app. The practice is accepting new Medicare patients and offers online submission for new patients and updates for existing patients prior to arrival. It holds a rating of 4.40 based on 342 reviews. The provider team includes family medicine physicians Eric Cole, MD, Robert J. Karl, MD, Mark A. Knipfer, MD, Lee B. Taylor Jr, MD, and Douglas Wiley, DO, along with family nurse practitioner Ramona R. Hrysikos, FNP, and physician assistant Seth Smith, PA-C. Dr. Cole serves patients from children through geriatrics, focusing on preventative medicine, cardiovascular disorders such as hypertension, and metabolic disorders including diabetes and high cholesterol, and serves as team physician for Wofford College. Dr. Karl brings over 25 years of patient service experience with interests in prevention, cardiovascular disease, lipid disorders, diabetes, and hypertension. Dr. Knipfer focuses on wellness and complete physical exams, lipid disorders, metabolic syndromes, diabetes management, and pediatric care. Dr. Taylor treats patients from newborn to geriatric with interests in cardiac health, lipid disorders, cholesterol treatment, wellness examinations, and diabetes. She previously worked as a Certified Diabetes Care and Education Specialist for more than 12 years at Mary Black Hospital and as an Inpatient Diabetes Care and Education Specialist with Spartanburg Regional Health System. Her professional focus centers on diabetes care, management, and women's health. Seth Smith, a board-certified physician assistant since 2019, joined the practice in June 2025 after providing emergency medical care throughout the Upstate with Medical Group of the Carolinas-Emergency Medicine. The practice also maintains dedicated administrative, scheduling, and billing teams that support patient experience, and new patient forms are available online. The practice has built an established track record on a large base of customer reviews and holds a solid reputation among the patients it has served. Family Physicians of Spartanburg draws on decades of local experience to provide accessible primary care for families across the Upstate.

Family Physicians of Spartanburg sits on Reidville Road in Spartanburg, about 0.1 miles from SRHS Immediate Care and the road itself, with the Brad Sill Golf Center roughly 0.5 miles away.

Family Physicians of Spartanburg earned a BizScoreAI Technical score of 93 out of 100, which means the website is technically sound, secure and indexable so search engines can read it without errors. The practice also ranks number 2 of 3 Medical clinic businesses that BizScoreAI has scored in Spartanburg.

Services:

• Digital X-Rays
• Echocardiography Services
• Onsite Laboratory Services
• Physical Exams
• Ultrasounds