Ryan M. Mathern, M.D. of Murrells Inlet

Ryan M. Mathern, M.D. is a pain management physician in Murrells Inlet, SC, specializing in nonsurgical solutions for bone, joint, muscle, and nerve conditions. He serves patients throughout the Grand Strand region, focusing on interventional spine and musculoskeletal medicine with expertise in epidural steroid injections, joint and sacroiliac injections, radiofrequency ablation, and nerve conduction studies. Dr. Mathern is fellowship-trained in interventional spine and musculoskeletal medicine and utilizes evidence-based treatments including non-opioid medications, home exercises, physical therapy, and advanced diagnostics to restore function and reduce pain. His care plans are tailored to each patient’s unique needs, with a focus on helping individuals return to work and the activities they love. He is highly rated with a 5.00 average from 145 verified reviews, reflecting strong patient satisfaction and trust.

Dr. Mathern graduated with a Bachelor of Science in bioengineering from The Pennsylvania State University and earned his Doctor of Medicine at Cooper Medical School of Rowan University. He completed his internship at North Florida Regional Medical Center and his physical medicine and rehabilitation residency at Atrium Health Carolinas Rehabilitation. His fellowship in interventional spine and musculoskeletal medicine was completed at the Hospital of the University of Pennsylvania. He approaches patient care with a holistic focus, considering physical, mental, and social well-being. Outside of medicine, he enjoys fitness, fishing, and supporting Philadelphia sports teams.

Located on Frontage Road in Murrells Inlet, the practice is part of OrthoSC’s network of care centers serving the region with on-site services including X-rays, MRI scans, physical therapy, and nerve testing. The office is situated within a medical corridor that supports accessible, comprehensive musculoskeletal care.

Dr. Mathern is recognized for his thorough, well-documented approach and the clarity of his online presence, which reflects both professional credibility and patient-centered service. His dedication to evidence-based, individualized treatment has solidified his reputation as a trusted specialist in pain management and rehabilitation. As a key member of OrthoSC, he continues to expand access to high-quality, nonsurgical care in Murrells Inlet and the surrounding communities.

Services:

• Electromyography (EMG)
• Interventional Pain Medicine
• Interventional Spinal Procedures
• Magnetic Resonance Imaging (MRI)
• Minimally Invasive Treatments
• Nerve Conduction Velocity
• Non-Surgical Solutions for Bone, Joint, Muscle, and Nerve Problems
• Pain Management